Peter M T Deen Selected Research

Nephrogenic Diabetes Insipidus

1/2021	Genetic background determines renal response to chronic lithium treatment in female mice.
12/2019	Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.
1/2018	Lithium induces aerobic glycolysis and glutaminolysis in collecting duct principal cells.
1/2017	Lithium-induced NDI: acetazolamide reduces polyuria but does not improve urine concentrating ability.
7/2016	Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus.
6/2016	Lithium in the Kidney: Friend and Foe?
4/2014	X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking.
3/2014	Lithium causes G2 arrest of renal principal cells.
3/2014	Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter.
12/2012	Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus.

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Peter M T Deen Research Topics

Disease

29	Nephrogenic Diabetes Insipidus 01/2021 - 02/2002
7	Polyuria 01/2017 - 05/2004
5	Bipolar Disorder (Manic Depressive Psychosis) 12/2019 - 06/2016
5	Hyponatremia 01/2018 - 03/2011
4	Dehydration (Water Stress) 01/2018 - 07/2009
4	Polydipsia 03/2015 - 05/2004
3	Body Weight (Weight, Body) 01/2017 - 03/2015
3	Hypernatremia 12/2012 - 09/2008
2	Pheochromocytoma 01/2021 - 01/2021
2	Paraganglioma (Paragangliomas) 01/2021 - 01/2021
2	Chronic Renal Insufficiency 01/2021 - 01/2017
2	Fibrosis (Cirrhosis) 01/2021 - 03/2014
2	Hypercalcemia (Milk Alkali Syndrome) 12/2019 - 07/2016
2	Acidosis 12/2019 - 07/2016
2	Diabetes Insipidus 12/2019 - 07/2009
2	Inappropriate ADH Syndrome (SIADH) 01/2018 - 12/2013
2	Acute Kidney Injury (Acute Renal Failure) 12/2017 - 01/2017
2	Hypoxia (Hypoxemia) 01/2017 - 08/2011
2	Hypovolemia 12/2012 - 09/2008
2	Hypertension (High Blood Pressure) 08/2011 - 12/2009
2	Nocturnal Enuresis (Bedwetting) 03/2002 - 02/2002
1	Atrophy 01/2021
1	Neoplasms (Cancer) 01/2021
1	Weight Loss (Weight Reduction) 10/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2017
1	Albuminuria 01/2017
1	Inflammation (Inflammations) 01/2017
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2017
1	Diabetes Mellitus 01/2017
1	Hyperkalemia 07/2016
1	Chronic Kidney Failure (Chronic Renal Failure) 06/2016
1	Polycystic Kidney Diseases (Polycystic Kidney Disease) 10/2014
1	Mycoses (Diseases, Fungus) 09/2014
1	Seizures (Absence Seizure) 08/2013
1	Disease Susceptibility (Diathesis) 08/2013
1	Proteinuria 08/2013
1	Ataxia (Dyssynergia) 08/2013
1	Intellectual Disability (Idiocy) 08/2013
1	Hemorrhage 08/2013
1	Metabolic Diseases (Metabolic Disease) 08/2011
1	Diabetes Complications 08/2011
1	Hyperglycemia 08/2011
1	Ischemia 08/2011
1	Mental Disorders (Mental Disorder) 03/2010
1	Hyperthermia 03/2010
1	Skin Diseases (Skin Disease) 06/2009
1	Histiocytosis with joint contractures and sensorineural deafness 06/2009
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2009

Drug/Important Bio-Agent (IBA)

20	Aquaporin 2IBA 10/2018 - 02/2002
18	Vasopressins (Vasopressin)IBA 01/2018 - 04/2002
14	LithiumIBA 01/2021 - 04/2006
8	Aquaporins (Water Channels)IBA 01/2018 - 03/2002
4	Succinic Acid (Succinate)IBA 01/2021 - 12/2009
4	Arginine Vasopressin (Argipressin)IBA 04/2014 - 10/2005
3	Hormones (Hormone)IBA 04/2014 - 01/2010
3	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 06/2011 - 05/2008
3	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 05/2004 - 02/2002
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2021 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 12/2017
2	Insulin (Novolin)FDA Link 01/2017 - 06/2009
2	Acetazolamide (Diamox)FDA LinkGeneric 01/2017 - 07/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 01/2017
2	ThiazidesIBA 07/2016 - 03/2015
2	Amiloride (Midamor)FDA LinkGeneric 07/2016 - 07/2009
2	SodiumIBA 03/2015 - 03/2011
2	Adenylyl Cyclases (Adenylyl Cyclase)IBA 12/2013 - 04/2006
2	ElectrolytesIBA 03/2011 - 08/2006
2	Biological ProductsIBA 08/2006 - 09/2002
1	Indicators and Reagents (Reagents)IBA 01/2021
1	CatecholaminesIBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2018
1	CreatinineIBA 12/2017
1	Cystatin CIBA 12/2017
1	Lipocalin-2IBA 12/2017
1	Blood Glucose (Blood Sugar)IBA 01/2017
1	Glycogen Synthase Kinase 3IBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 03/2015
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 10/2014
1	Metformin (Glucophage)FDA LinkGeneric 09/2014
1	Protein Kinases (Protein Kinase)IBA 09/2014
1	Adenosine Monophosphate (AMP)IBA 09/2014
1	Sodium Chloride SymportersIBA 03/2014
1	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 03/2014
1	Demeclocycline (Declomycin)FDA LinkGeneric 12/2013
1	Cytidine Monophosphate N-Acetylneuraminic AcidIBA 08/2013
1	sialic acid transport proteinsIBA 08/2013
1	DiureticsIBA 12/2012
1	LigandsIBA 08/2011
1	Proteins (Proteins, Gene)FDA Link 03/2011
1	Serotonin (5 Hydroxytryptamine)IBA 03/2010
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 03/2010
1	Dopamine (Intropin)FDA LinkGeneric 03/2010
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 03/2010
1	ReninIBA 12/2009
1	Peptide Hormones (Polypeptide Hormones)IBA 07/2009
1	Sodium Channels (Sodium Channel)IBA 07/2009
1	Amino Acids FDA Link 01/2007

Therapy/Procedure

4	Therapeutics 01/2021 - 08/2006